News: The Non-Hallucinogenic Psychedelic Pipeline Tracker

Sponsor Drug/Program Name Phase Indication(s) Description Related Compound/Class
2A Biosciences Unnamed Discovery/Preclinical Ocular neurodegeneration, undisclosed neuropsychiatric disorders
Alexander Shulgin Research Institute ASR-2001 Discovery/Preclinical 5-HT2A/2B Agonist Phenethylamine
Arcadia Medicine AM-1006 Discovery/Preclinical SUDs "Subperceptual psychoactive drug"
AtaiBeckley EGX-121 and others Discovery/Preclinical OUD & TRD "non-tryptamine NCE"
BetterLife Pharma BETR-001 Discovery/Preclinical MDD; Anxiety Disorder; Neuropathic Pain BOL-148 BOL-148
Bright Minds Biosciences BMB-201 Discovery/Preclinical Depression, Pain, Headache 5-HT2A/2C Agonist
Ceruvia Lifesciences NYPRG-101 Phase I Migraine; Headache Disorders; Alcohol and Opioid Use Disorder BOL-148 LSD/BOL-148
Collaborations Pharmaceuticals Psychoplastogens Discovery/Preclinical OUD "5HT2A Partial Agonist" and "5HT2C Agonist"
Delix Therapeutics DLX-001 Phase I MDD Zalsupindole / AAZ-A-154 5-MeO-DMT
Delix Therapeutics DLX-007 Discovery/Preclinical SUDs Tabernanthalog Iboga
Delix Therapeutics Various NCEs Discovery/Preclinical
Elkedonia Various neuroplastogens Discovery/Preclinical Undisclosed
Enveric Biosciences EB-003 Discovery/Preclinical Undisclosed psychiatry "engages both the 5-HT2A and 5-HT1B receptors"
Equulus Theraeputics EQL-101 Discovery/Preclinical Substance Use Disorders Non-hallucinogennic ibogaine derivative Ibogaine / 18-MC derivative
Five Discovery FVE-101 Discovery/Preclinical Levodopa-induced duskinesia, Parkinsons disease, TBI 5-MeO-DMT inspired 5-MeO-DMT
Five Discovery FVE-102 Discovery/Preclinical Alzheimer's Disease 5-MeO-DMT inspired 5-MeO-DMT
Gilgamesh Pharmaceuticals GM-5022 Discovery/Preclinical "Depression, Anxiety, and Others" "Oral neuroplastogen" (partnered with AbbVie)
J&J ITI-1549 Discovery/Preclinical Mood and neuropsychiatric disorders Pyridopyrroloquinoxaline family
Küleon Bioscience KB-128 Discovery/Preclinical Alcohol Use Disorder 5-HT2C agonist
Marvel Biosciences Corp Various neuroplastogens Discovery/Preclinical "...a set of molecules inspired by the tryptamine class of psychedelics" Tryptamines
Negev Labs / Parow Entheobiosciences HBL20017 Discovery/Preclinical OCD
Ocellaris Various NCEs Discovery/Preclinical Neuropsychiatry
Psilera PSIL-006 Discovery/Preclinical Frontotemporal Dementia Company's lead candidate Psilocybin
Psilera PSIL-006 Prodrugs Discovery/Preclinical Dementias & AUD Psilocybin
Psilera PSIL-025 Discovery/Preclinical Anxiety Disorders Psilocybin
Reunion Neuroscience RE245 Discovery/Preclinical Undisclosed
Seaport Therapeutics SPT-348 Discovery/Preclinical Headache Disorders; TRD BOL-148 prodrug LSD/BOL-148
Tactogen TACT908 Discovery/Preclinical Cluster Headache 5-HT1B/2A Agonist DMT
Transneural Therapeutics Exploratory Programs Discovery/Preclinical Parkinson's and other neurodegenerative conditions "Diverse serotonergic programs (e.g., 5-HT2C Agonist)
Transneural Therapeutics TN-001 Discovery/Preclinical MDD; PTSD Dual 5-HT2A Partial Agonist / 5-HT2B Antagonist Neuroplastogen
Transneural Therapeutics TN-002 Discovery/Preclinical Migraine/Chronic Pain 5-HT2B Antagonist
Xylo Bio XYL-1001 Discovery/Preclinical Depression Selective 5-HT2A agonist
Xylo Bio XYL-200X Discovery/Preclinical Anxiety Multi-target 5-HT2A agonist
Xylo Bio XYL-300X Discovery/Preclinical Undisclosed Neurology
Xylo Bio XYL-400X Discovery/Preclinical SUDs

Explore the entire psychedelic pipelineView the Psychedelic Drug Development Tracker

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