Read our independent data-driven reporting, analysis and commentary on the psychedelics space: from business and drug development through to policy reform and culture.
Our work is reader-supported. Sign up to our free or paid plans here.
Psychedelic Alpha’s Josh Hardman sits down with Compass Pathways’ Chief Patient Officer, Steve Levine, at a pivotal time for the company. In this wide-ranging discussion, the pair cover these commercialisation-related topics, from the clinical infrastructure and credentialing through to comps and competition.
The Advanced Research Projects Agency for Health (ARPA-H) has carved out up to $100M for an initiative that aims to develop objective measures of mental and behavioural health, it announced today. Here, we take a closer look about ARPA-H’s first major foray into mental health, and how it could catalyse psychedelic drug development and practice.
Largest LSD Microdosing Trial to Date Fails Across All Endpoints • AtaiBeckley’s Phase 2b Debrief: More Detail on SAE and Phase 3 Considerations • UK Government Holds Line on Psilocybin Despite New Cross-Party Written Questions • MAHA Summit Features Psychedelics • VA Reveals Phase 3 Psilocybin Study • Task Force Calls for Psilocybin Decrim • and more…
In this interview with Psychedelic Alpha’s Josh Hardman, psychiatrist, therapist and researcher Dr. Óscar Soto discusses psychedelic trial design, therapeutic fidelity, and the evolving role of subjective experience in psychedelics and psychiatry. He also shares his views from the field, with a particular focus on clinical trials of 5-MeO-DMT.
This morning, AtaiBeckley shared positive topline data from the open-label portion of its Phase 2b trial of intranasal 5-MeO-DMT (BPL-003) in patients with treatment-resistant depression (TRD), which offered a second dose to many participants. That second dose, it reports, led to additional rapid antidepressant effects that were sustained for up to 8 weeks. We reviewed the readout and spoke with CEO, Srinivas Rao, to dive a little deeper…
Compass Pathways Accelerates Psilocybin Launch Plans by Almost a Year • Australia’s VA Will Fund Psychedelic-Assisted Psychotherapy for Veterans • AbbVie Paid $900M Upfront for Gilgamesh’s Psychedelic Candidate • AtaiBeckly Is Born • MindMed Closes $259M Public Offering • European Psychedelics Group Pens Letter to European Commission President • and more…
Through our years of reporting we have covered many of the topics we believe to be important to the present and future of the psychedelics space, broadly defined. However, much of this commentary is scattered across Bulletins, deep dives, special reports and year-end reviews.
The Library provides digestible explainers on salient topics across psychedelic drug development, policy and business: from basic explainers such as “what is psychedelic-assisted therapy?” through to more complex matters such as REMS programs and bifurcated scheduling.
It’s exclusively available to our Pα+ subscribers, with new content added regularly.
Pα+ Library: we introduce some of the key concepts in the matter of bifurcated scheduling; a process by which an approved drug product may be placed in a different schedule to the substance itself. As we discuss in this piece, this could have significant repercussions for psychedelic research, legality, and even taxes.
Pα+ Library: we sketch out what a psychedelic REMS might look like, highlighting how these programs could have an outsized impact on the post-approval delivery and accessibility of these treatments.
The Psychedelic Practitioner by Psychedelic Alpha is a new publication designed specifically for therapists, clinicians, facilitators, and other professionals working with—or preparing to work with—psychedelic therapies and related treatments.
The Psychedelic Practitioner by Psychedelic Alpha is a new publication designed specifically for therapists, clinicians, facilitators, and other professionals working with—or preparing to work with—psychedelic therapies and related treatments.
Archived versions of our Psychedelic News Feed.
Your one-stop digest for the latest coverage of psychedelics business, policy, research and beyond, for the week commencing November 17, 2025.
Your one-stop digest for the latest coverage of psychedelics business, policy, research and beyond, for the week commencing November 22, 2025.
Your one-stop digest for the latest coverage of psychedelics business, policy, research and beyond, for the week commencing November 3, 2025.
Your one-stop digest for the latest coverage of psychedelics business, policy, research and beyond, for the week commencing October 27, 2025.
Your one-stop digest for the latest coverage of psychedelics business, policy, research and beyond, for the week commencing October 20, 2025.
Your one-stop digest for the latest coverage of psychedelics business, policy, research and beyond, for the week commencing October 13, 2025.
Psychedelic Alpha is an independent newsletter and community that strives to empower a diverse constellation of individuals and organisations with the knowledge, network and nuance to make an impact within the field of psychedelic medicine and beyond
Insights and interviews delivered to your inbox. No spam, just valuable information.
