This Week:
- āļø Lawsuit alleges Compass Pathways “milked” researcher for trade secrets before “secretly” filing patent on same technology
- š¤ Exclusive: Tweet from Compass Account Calls Terran āslimeā and Lawsuit āPublicity ployā ā Compass Blames Hack
- šļø Californiaās Decrim. Bill Tentatively Passes Final Hurdle Before Heading to the Floor
- šŖ§ Former MindMed Chief Medical Officer Launches Effort to Effect Drastic Changes
- š¤ Opinions | Hallucinations of Meaning: If you can lie, so can psychedelics
and more…
Psychedelic Sector News
Compass āmilkedā researcher for trade secrets before āsecretlyā filing patent on same technology, alleges lawsuit
This weekās drama comes courtesy of Terran Biosciences, which alleged in a lawsuit filed on the 5th August that Compass Pathways stole trade secrets from a University of Maryland, Baltimore (UMB) researcher Dr. Scott Thompson then filed patents claiming them.
Why does Terran care? Well, in 2021 the stealth biotech company inked an exclusive licensing deal for a suite of psychedelic-related patents and data from UMB. Thompsonās work was among it.
Thompson researches methods of antidepressant drug action, and depression itself, in his role as professor of physiology at UMB. According to the lawsuit filed by Terran, Thompson has been working on the āidea of co-administration of psilocybin with a 5-HT2A antagonistā since 2016. The purpose of this co-administration would be to tamp down or eliminate the hallucinogenic effects of a psychedelic (in this case psilocybin) while maintaining any therapeutic (in this case antidepressant) effects.

While research into non-hallucinogenic psychedelicsāthe pursuit of uncovering whether the apparent therapeutic effects of psychedelics can be decoupled from the ātripāāhas become a hot topic lately, researchers like Thompson had theorised their potential years ago; at least in the case of psilocybin and a 5-HT2A antagonist like ketanserin.
Thompson and UMB filed patent applications on this work, which the lawsuit claims to be āthen-trade secret inventionsā. We wrote about one such UMB patent application back in May (#102) when discussing MindMedās (now lesser-spotted) ātrip neutralizerā program, along with another patent application on psychedelic tryptamines and 5-HT2A antagonists filed by Blumentech with the late Dr. Jordi Riba as a co-inventor (and which Terran also acquired).
According to the suit, Thompson kept this research confidential, not disclosing it outside of the scope of an NDA or other confidentiality agreement.
In May of 2019, the complaint claims that Compass reached out to Thompson to discuss a potential partnership. The company implied that it was āexcited about an opportunity to work together,ā the lawsuit alleges.
After entering into a mutual NDA Terran alleges that, āin reliance on the NDA,ā Thompson engaged in ānumerous substantive discussions and negotiationsā with Compass. This purportedly included his disclosing of these trade secrets to the company.
In short, Terranās lawsuit alleges that “Compass milked Thompson for all the information it could about his confidential research.” Then, “Compass misappropriated the Psilocybin Trade Secrets for itselfā, and āsecretly filed its own patent application” covering the co-administration described above.
According to the suit, on a phone call with Thompson in September 2019 Compass asked whether he had filed any patent applications. When he informed them that he had done so on August 13th, just over two weeks prior to Compassā August 29th filing, the suit alleges that Compass ābecame notably upset.ā
Around 6 months after it began negotiations with Thompson, Compass āabruptlyā ended its talks with the researcher in November 2019, according to Terranās filing.

But, given that Thompsonās patent application was filed a fortnight prior to Compassā, why all the hoopla?
Regardless of whether Thompsonās application might preclude Compass from obtaining any claims (as it would presumably represent prior art), Terran is looking to realise injunctive relief and damages.
In terms of injunctive relief, Terran hopes to prevent Compass from utilising or disclosing the alleged trade secrets. In addition, Terran will look to compel Compass to turn over information that pertains to how the trade secrets were utilised or transmitted with and beyond Compass. This could include handing over documents and plans that contain the psilocybin-plus-5-HT2A-antagonist technology, as well as identifying persons or other entities that are aware of it.
Terran also seeks an order requiring Compass to assign to Terran āany rights to patent applications or other intellectual property that incorporates the Psilocybin Trade Secrets.āĀ
Co-administration of psilocybin and a 5-HT2A antagonist is disclosed in at least Compassā WO2020212951A1 (āMethods for treating anxiety disorders, headache disorders, and eating disorders with psilocybinā, notable given Compassā recent launch of its phase II anorexia trials), WO2020212952A1 (āTreatment of depression and other various disorders with psilocybinā, perhaps best known for its soft furniture), WO2020212948A1 (āMethods of treating neurocognitive disorders, chronic pain and reducing inflammationā), and all of their foreign and national stage counterparts, which ultimately could total in the dozens.
If Terran could sell this āfruit of the poisonous treeā theory (see Lemley, 2017), Compass would have to hand over the lionās share of its psilocybin IP portfolio, even though the coadministration of psilocybin with a 5-HT2A antagonist is surely not the primary subject. Terran is also seeking damages and costs.
Itās difficult to appraise the motives of a plaintiff in the best of times, but given Terranās secretive nature itās closer to impossible. We know very little about the company, which has been in stealth since 2017 and claims to have hundreds of psychedelic patent applications in its portfolio. When news broke that the startup had licenced assets from Sanofi earlier this year, we provided a short recap about whatās known of the company; which largely revolves around a handful of licensing agreements.
A more cynical observer might wonder if this alleged misappropriation of trade secrets might be the impetus for a fishing expedition of sorts. If Terran convinces the Judge to compel Compass to turn over sensitive documents and plans, and make corporate representatives available for deposition testimony, they might come away with intelligence worth more than any straightforward monetary award. Of course, this is pure speculation.
Itās also very important to remind readers that this lawsuit represents just one side of the story: a story told by Terran Biosciences with neither Thompson nor UMB are included as plaintiffs (Thompson did take to Twitter to describe Compassā alleged behaviour as, āShamefulā).
Compass Pathways told us that, while it takes the allegations seriously, it āstrongly disagree[s] with the claimsā and is āconfident that the facts will ultimately bear this out.ā The company told us that it is considering its own legal options in response.
Terran declined to comment.

Exclusive: Tweet from Compass Account Calls Terran āslimeā and Lawsuit āPublicity ployā ā Compass Blames Hack
In the course of writing-up this piece we felt that even mentioning the possibility of a fishing expedition on Terranās part was overly cynical.
Thatās until a tweet steeped in even more cynicism came to our attention. The tweet was posted in response to a thread we wrote as the news broke, and read:
Publicity ploy for Terran. What slime
What surprised us was that the tweet was posted from Compass Pathwaysā Twitter account (ownership of the account was confirmed to Psychedelic Alpha in writing).
We reached out to Compass, who told us that āCOMPASS did not make this commentā. A representative from the company went on to tell us that they would āassume we have been hackedā.
The tweet was deleted within minutes of being posted.
Californiaās Decrim. Bill Tentatively Passes Final Hurdle Before Heading to the Floor
SB-519, which would generally decriminalise psychedelics in the state of California, appears to have passed another hurdle yesterday. California Senate Bills must run through a gauntlet of senate and assembly committees before reaching the floor.Ā
Thus far, SB-519 has the following scorecard in terms of committee votes:
- Senate Public Safety: Passed with a 4-1 vote (6th April, 2021)
- Senate Health: Passed with a 6-2 vote (14th April, 2021)
- Senate Appropriations: Passed with a 5-2 vote (20th May, 2021)
- Senate Floor: sent to the Assembly in a 21-16 vote (1st June, 2021)
- Assembly Public Safety: Passed with a 8-4 vote (29th June, 2021)
- Assembly Health: Passed with a 8-4 vote (13th July, 2021)Ā
As you can see, the Bill passed through the requisite Senate committees and two Assembly committees last year before being put on pause just under a year ago in order to build a coalition to earn the support of Assembleymembers.
Yesterday, the Assembly Appropriations Committee voted 9-5 to endorse the motion do pass as amended. Frustratingly, however, the full text of the amendmentsāwhich are thought to be significantāis not available at the time of writing. Even Senator Scott Wiener, who is forwarding the Bill, is awaiting final clarity on such amendments.
The confusion is enormous, as Kyle Jaeger reports in Marijuana Moment:
āItās not immediately clear if the amendment deletes the billās criminal justice reform provisions that would have removed penalties for possessing certain substances and only maintains a section directing state officials to establish a working group to study and make recommendations regarding future psychedelics reformāor if the opposite occurred, meaning that the main thrust of the bill survives and the study itself was taken out.ā
LA Times reporter Hannah Wiley implied, on Twitter, that this lack of transparency around amendments is par for the course for this committee.
If the amendments are reflected in the Bill, SB-519 should progress to the Assembly Floor for a full vote.
Former MindMed Chief Medical Officer Launches Effort to Effect Drastic Changes in Shareholder Activist Turn
āYou Are Entering The MindMed Zoneā, reads the landing page of an odd website and accompanying press release that began circulating around MindMed investor forums yesterday. The communications were published by āFCM MM HOLDINGS, LLCā (FCM), which claims to represent āinvestments in 5.64%ā of MindMedās outstanding shares.

The group is spearheaded by Dr. Scott Freeman, MindMedās first Chief Medical Officer (CMO) after the company acquired Savant HWP where he also served as CMO. Dr. Freeman wasnāt at MindMed for long. He was the first senior member of the team out the door, in fact, leaving the company around a year after he joined. MindMed did not immediately respond to Psychedelic Alphaās request for comment on any of the matters discussed herein, but a representative from FCM said they could not divulge the reason for Freemanās departure due to a non-disclosure agreement.

Despite proclaiming that āThe Founders Are Backā on its website, the groupās two other members would struggle to identify themselves as such. Chad Boulanger is Director of āObiter Researchā (save yourself a Google, we cover it later) and was also a Director at Savant HWP during Scott Freemanās time as CMO. The final member of the trio is Scott Freemanās 20-year old nephew, Jake Freeman.
Jake Freeman is a curious character, who just last month penned a letter to Bed Bath & Beyondās Board of Directors after accumulating a sizable stake in the company. Freeman, a math major, suggested that the company āneeds to cut its cash-burn rate, drastically improve its capital structure, and raise cash.ā The action led to a flurry of discussions on a subreddit dedicated to Bed Bath & Beyond investors, who refer to the company as āBuy Buy Babyā. He also registered as an independent candidate for President in 2020. But, we digress.
While MindMedās former CMO, Scott Freeman, is the only member of the group with any claim to āfounderā status, his nephew Jake appears to be taking the helm. āThe strategic direction of the plan overall was mine along with the strategic plan for this activism,ā Jake commented on a Reddit AMA.
Despite repeatedly alluding to representing other members of MindMedās founding team, and āmany members of Savant,ā names are not forthcoming. Jake Freeman told Psychedelic Alpha that his group āinvolves former members and founders of MindMed,ā but that FCM ācannot comment on this as some members may be subject to agreements with MindMed which may prohibit engaging in shareholder activism.ā

In a Letter to the Board of MindMed, the trio outlined their āvalue enhancement planā which called for drastic cost-saving measures at the company. Like many other public psychedelics companies, MindMedās stock performance has been terrible of late. MNMD, which trades on the NASDAQ, is down nearly 60% year to date.
So, whatās FCMās prescription? Hereās the short answer:
- Scrap the at-the-market offering (which the group believes it can suspend via legal action)
- Slim down the drug development pipeline to focus on MM-110 (18-MC) and MM-120 (LSD)
- Slash compensation, especially among execs, and use share-based compensation to better align incentives
- Ditch digital health company HealthMode
- Re-appoint Scott Freeman as Chief Medical Officer
The group would have been dismayed, then, to hear MindMedās direction as discussed in the companyās Q2 financial results and conference call yesterday (on which CEO Robert Barrow asked that those asking questions refrain from discussing FCMās letter).
While youād think FCM might be pleased to hear CEO Robert Barrowās emphasis on a ācost effective approach,ā the de facto shelving of MM-110āMindMedās 18-MC drug development program for the treatment of opioid withdrawalāis likely to upset the group.
MindMed explained that during the course of discussions with the FDA it became apparent that, in order to progress to a Phase 2a study of MM-110, they would need to present more nonclinical data to the agency. According to the company, in light of the time and costs associated with producing such data, MindMed will cease this drug development program. If non-dilutive funding comes along (such as in the form of a partnership), or material circumstances change, the company said it may revisit it.
But, as we have mentioned before: there are probably more fundamental commercial issues with the ibogaine derivative that have factored into MindMedās decision to drop its MM-110 program. For starters, 18-MC is now off-patent. Whatās more, MindMed faces little hope of obtaining meaningful IP protection over MM-110 due to the fact that the treatment of addiction was claimed in the earliest patents on the drug. This apparent lack of defensibility is likely, in our opinion, to weigh heavily on the companyās decision.
There are other wrinkles in the history of 18-MCās development, too.Ā
āāIn January 2013, Savant HWP announced a significant grant commitment from the National Institute on Drug Abuse (NIDA) to support its development of 18-MC. The grant, which totaled nearly $6.8 million over the course of its three year project lifespan, was in large part used to support Savantās IND-enabling studies of its flagship drug candidate which included dose finding, cocaine interaction, and cardiovascular effects studies.Ā
As principal investigator in the NIDA-funded research, Scott Freeman appears to have played a notable role in this stage of 18-MCās development. Following the completion of the three-year project, the group submitted a follow-up application for the continued support of research into 18-MC. However, for reasons reportedly unknown to even Stephen Hurst, NIDA denied Savantās grant second proposal (Hurst who told Wired in 2019 that āNo one ever actually told us whyā).
The apparent abandonment of MindMedās 18-MC program, and redistribution of funds to its LSD (MM-120) and R(-)-MDMA (MM-402) programs, has evidently upset the Freemans and Chad Boulanger. Thatās unsurprising, as they have been involved in the development of the drug for some time.
Letās back-up a littleā¦
Chad Boulangerās brother, Bill, is a chemist. The pair run Obiter Research out of Champaign, Illinois. A 2014 write-up in a local Illinois publication, News-Gazette, provides orientation for those looking to understand Obiter and Savantās dealings with 18-MC prior to the MindMed acquisition.
Essentially, Obiter was a specialty chemicals manufacturer that was looking for āa partner with deep pocketsā to help it pursue FDA approval for 18-MC in the treatment of addiction. Obiter, which licensed technology for 18-MC from Albany Medical College (where Stanley Glick et al. invented the ibogaine derivative), had worked with Savant but apparently became frustrated by the companyās āreluctance to contractually obligate itselfā to the development of the drug, according to Chad Boulanger.
Obiter and Savant presumably thought they had found those ādeep pocketsā in MindMed, which acquired the 18-MC project from Savant in 2019. This project became the āimmediate priorityā of MindMed and was the jewel in the companyās crown for some time.

Just as Obiter was frustrated by Savantās reluctance to throw itself behind 18-MC back in 2014, it appears that both Obiter and Savantāor, Scott Freeman and Chad Boulanger, at leastāare today frustrated at MindMedās unwillingness to back the drug.
Thereās plenty of skin in the game for FCM, tooā¦ Jake Freeman told Psychedelic Alpha that all three members of FCM have shares locked up in Savant, with the total in excess of 8 million shares.
Itās unclear whether FCMās stunt will remain just that, or whether it will progress into a fully-fledged shareholder activism campaign. āPotentially, we are prepared to launch a full activity campaign to change management’s strategic directionā, FCMās Jake Freeman said.
Editorās note: today, the day after shelving its potential opioid use disorder treatment (18-MC), MindMed announced it has appointed Roger Crystal to its Board. Crystal is the lead inventor of the incredibly popular opioid overdose treatment, Narcan (Naloxone), and is widely regarded as an authority on the opioid crisis. MindMed somehow managed to avoid using the word āopioidā once in the Press Release.
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Weekend Reading
Opinions | Hallucinations of Meaning: If you can lie, so can psychedelics
We are very pleased to share the first article via our Opinions series. This piece explores whether psychedelics might amplify our self-deception, and whether we can tell truly meaningful psychedelic insights from misleading ones.
Itās written by Abigail Calder, a doctoral candidate in medical neuroscience at the University of Fribourg, Switzerland. Her research focuses on the effects of LSD on neuroplasticity, learning, memory, and other topics in healthy people. She also leads a study investigating the side effects of various psychedelic drugs. When she doesn’t want to think about psychedelics anymore, she goes rock climbing or crochets a tiny animal.
Here’s an excerpt of the full piece:
A common first sign of a psychedelic taking effect is the feeling that something important is happening. There is a sense of something big and significant approaching ā a mental pregnant pause before the world starts to change. People usually cannot tell youĀ whatĀ is happening. They just know that something is.
This shows something important: psychedelics can cause a sense of meaning and significance without any content. Later, the experience overflows with content, served with a side of āWowā and a sense that itās all important. Whatever network in the brain creates feelings of meaning, psychedelics seem to send it into overdrive.
But therein lies the trouble. If psychedelics can cause the feeling of significance without any content, why couldnāt they do it withĀ falseĀ content? I donāt doubt that some psychedelic insights are real in ways that are important to people. But if you can hallucinate sights and sounds, why not meaning? Why not knowledge, memory, and insight?
Thatās an uncomfortable question because the natural next question has no easy answer: How does one tell the real insights from the misleading ones?
Assorted Weekend Reading
Thereās plenty to read this weekendā¦
- Mass General Hospitalās Proto Magazine: Where Psychedelic Research Goes Next. A great read that takes a look at the different branches of psychedelic research, from fundamental neuroscience through to addressing methodological issues like placebo controls (or lack thereof).
- Petition: āReschedule psilocybin for medical research on untreatable conditions,ā demands a petition directed at the UK Government.
- STAT News: Psychedelics researchers and investors should focus on delivering therapy, not drugs. Philanthropist and investor Michael Pollack argues that drug discovery and development is receiving too much attention: itās the therapeutic container that matters, he argues.
- Lucid News: Young Psychedelic Philanthropist Blazes Path for the Psychedelic Future. Marc Guntherās latest story over at Lucid profiles Cody Swift.
- Psychedelic Science Review: Buried Treasure: How Does Psilocybin Reduce Compulsivity?
- Financial Times: Psychedelics are the latest employee health benefit. Enthea, a psychedelic benefit plan administrator, says that 8% of the 450 Dr. Bronner’s employees on its program have used the ketamine therapy benefit thus far. They also claim to have at least 25 other companies interested.
- Wisconsin Public Radio: interviews Usona Institute founder, Bill Linton.
- Economist: Ann Shulgin pioneered the use of psychedelics in therapy.Ā
- MIT Technology Review: Psychedelics are having a moment and women could be the ones to benefit.Ā
- Independent: Over the counter culture: Are psychedelics coming to the corner shop? In his latest psychedelics reporting, Kevin E G Perry uses Pollanās Netflix docuseries as a jumping off point to assess their continued prohibition.
- BBC Business Daily Podcast: The power of fungi. BBC World Serviceās News program talks to psychedelic researcher Albert Garcia-Romeu, as well as fungi experts at Kew Gardensā Fungarium and a Finnish āfungally-focussedā company.
- Psychedelics ETF to shutter: Defiance Next Gen Altered Experience ETF (PSY) is closing, with liquidation to take place after the close of business on August 30th.
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